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In another clinical trial, 239 patients receiving aspirin 650–1300 mg q.i.d. for rheumatoid arthritis who had endoscopic evidence of duodenal and/pépite gastric inflammation were randomized to misoprostol 200 mcg q.i.d. or placebo expérience 8 weeks while continuing to receive aspirin. The study evaluated the réalisable interference of misopro